Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 199 Reviews
8.4
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
Most Useful Reviews
10
Joint pain relief
341 people found this helpful
Excellent! Effective even in advanced cases. I took it to my parents and grandmother, who have suffered from knee joint issues for many years. It's been a month since they forgot about all the ointments and creams. After physical exertion or an active day, there are no problems with their legs. This is very encouraging!
Read More
9
Significant pain relief
276 people found this helpful
Excellent!!! After starting these miraculous vitamins, I felt a significant improvement in my shoulder pain. I have struggled with this discomfort from a shoulder injury. I've previously tried ointments and tablets with little success. Now, I can go hours without checking on the pain. It’s astonishing!
Read More
9
Disappearance of pain
163 people found this helpful
This medication is one of the best for worn joints. With regular use, the pain disappears, and I feel much better overall.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
Read More
9
We explored the impact of high molecular weight sodium hyaluronate (HMW-HA) on pelvic pain caused by radiation-induced cystitis. In this prospective study involving 30 patients across seven centers in France, participants received six weekly intravesical instillations of HMW-HA.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
This study looked into how well hyaluronic acid (HA) treatments help relieve pelvic pain in patients with bladder pain syndrome and urinary tract infections. We found that, after long-term use, patients experienced significant reductions in symptoms like urinary bladder pain and urgency. Remarkably, around 75% of participants saw complete relief and needed no further treatments.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Read More
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 199 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Joint pain relief
341 people found this helpful
Excellent! Effective even in advanced cases. I took it to my parents and grandmother, who have suffered from knee joint issues for many years. It's been a month since they forgot about all the ointments and creams. After physical exertion or an active day, there are no problems with their legs. This is very encouraging!
Read More
9
Significant pain relief
276 people found this helpful
Excellent!!! After starting these miraculous vitamins, I felt a significant improvement in my shoulder pain. I have struggled with this discomfort from a shoulder injury. I've previously tried ointments and tablets with little success. Now, I can go hours without checking on the pain. It’s astonishing!
Read More
9
Disappearance of pain
163 people found this helpful
This medication is one of the best for worn joints. With regular use, the pain disappears, and I feel much better overall.
Read More
8
Joint pain improvement
156 people found this helpful
A great helper for joint pain.
Read More
7
Reduced shoulder pain
156 people found this helpful
I have issues with my shoulder joints, and without supplements every three months, my movements were painful. After adding hyaluronic acid, I've noticed significant improvement—my mornings are much easier, with fewer noises from my shoulders.
Read More
Frequently Asked Questions
9
Joint pain gone
40 people found this helpful
At 42 years old with stage II gonoarthrosis, I took 2 capsules daily along with Teraflex and vitamin C. My pelvic pain has almost completely disappeared, making daily activities much easier. The improvement in my skin quality adds to my satisfaction with the product. I recommend it for joint issues; it has genuinely helped.
10
Unexpected knee relief
26 people found this helpful
After three days, I experienced no knee pain! I had been suffering from it when going up and down stairs for about four years. At its worst, it was debilitating. Looking for a solution that wasn’t merely a pain reliever, I opted for this product after researching H.A. Over just three days of use, my knees felt remarkably better. I can now go downstairs with my daughter without the dread of pain. I find it incredible how quickly the improvement came!
9
Cumulative effect noted
22 people found this helpful
Good product; this is my second purchase. The additive improved my joint sensations, but notably, it has positively affected my skin! I am very satisfied. I would like to add that the effect seems cumulative, as my knees no longer crackle and the pain has subsided. It’s a brilliant product!
10
Joint pain relief
341 people found this helpful
Excellent! Effective even in advanced cases. I took it to my parents and grandmother, who have suffered from knee joint issues for many years. It's been a month since they forgot about all the ointments and creams. After physical exertion or an active day, there are no problems with their legs. This is very encouraging!
9
Significant pain relief
276 people found this helpful
Excellent!!! After starting these miraculous vitamins, I felt a significant improvement in my shoulder pain. I have struggled with this discomfort from a shoulder injury. I've previously tried ointments and tablets with little success. Now, I can go hours without checking on the pain. It’s astonishing!
10
Near pain-free movement
14 people found this helpful
Fantastic Arthritis Product! Before trying this, my doctor suggested knee replacement due to severe arthritis pain. Concerned, I opted for this product because its components mimic the injections I was getting. After just three days, the pain was mostly gone, and now, one month on, I'm nearly pain-free. It's surprising that doctors don't recommend it for arthritis relief.
9
Pain alleviation
13 people found this helpful
This formulation of hyaluronic acid with chondroitin has provided excellent results for my joints and skin. I’ve noticed my pelvic pain is gone and my skin quality has improved. I'm very pleased with how it hydrates and protects my body's surfaces. Highly recommended for anyone dealing with similar issues.
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
We analyzed the effects of Hyaluronic Acid-Chondroitin Sulfate (HA-CS) on women experiencing pelvic pain and urinary urgency due to interstitial cystitis/painful bladder syndrome (IC/PBS). Seventeen patients received this treatment while waiting for surgical intervention for urinary issues.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
8
We explored the effectiveness of combining hyaluronic acid (HA) with pirarubicin for patients recovering from non-muscle invasive bladder cancer. In a study involving 127 participants, we found that those receiving the combination treatment experienced quicker and more lasting relief from pelvic pain and urinary symptoms compared to those treated with pirarubicin alone.
Although the combination showed noticeable benefits in pain management, it did not significantly reduce cancer recurrence rates. Importantly, we observed no serious side effects related to hyaluronic acid treatment.
Although the combination showed noticeable benefits in pain management, it did not significantly reduce cancer recurrence rates. Importantly, we observed no serious side effects related to hyaluronic acid treatment.
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
References
- Gubbiotti M, Rubilotta E, Bacchiani M, Cocci A, Rosadi S, et al. Intravesical administration of highly concentrated hyaluronic acid and chondroitin sulfate as add-on therapy for chemical cystitis induced by Bacillus Calmette-Guérin (BCG) immunotherapy. Int Urol Nephrol. 2025. 10.1007/s11255-025-04375-8
- Falabella R, Morra S, Milella L, LA Falce S, DI Fino G, et al. Overactive bladder: results from patients treated by hyaluronic acid-chondroitin sulphate therapy. Minerva Urol Nephrol. 2024. 10.23736/S2724-6051.24.05786-0
- Porcaro G, Laganà AS, Neri I, Aragona C. The Association of High-Molecular-Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6, and Vitamin D Improves Subchorionic Hematoma Resorption in Women with Threatened Miscarriage: A Pilot Clinical Study. J Clin Med. 2024;13. 10.3390/jcm13030706
- Parente E, Colannino G, Bilotta G, Espinola MSB, Proietti S, et al. Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study. Clin Pract. 2023;13:1123. 10.3390/clinpract13050100
- Ghaith AF, Radwan MH, Rashed Taha M, Elbendary MA, Al Damhogy ME, et al. Evaluation of pain and quality of life after hyaluronic acid instillation in addition to botulinum toxin-A injection in women with refractory Interstitial Cystitis/Painful Bladder Syndrome: A pilot study. Arch Ital Urol Androl. 2022;94:447. 10.4081/aiua.2022.4.447
- Baboudjian M, Fourmarier M, Clement C, Cherasse A, Graziana JP, et al. Intravesical instillation of high molecular weight sodium hyaluronate in radiation-induced cystitis: a prospective pilot study. World J Urol. 2022;40:141. 10.1007/s00345-021-03837-9
- Argüelles Rojas S, Oviedo Ortega JG, Velasco Sordo R. Interstitial Cystitis: Diagnosis and Treatment in a Pregnant Patient. Cureus. 2021;13:e14549. 10.7759/cureus.14549
- Cai T, Gallelli L, Cione E, Verze P, Palmieri A, et al. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva Urol Nephrol. 2022;74:780. 10.23736/S2724-6051.21.04141-2
- Peng YC, Yueh-Hsia Chiu S, Feng M, Liang CC. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwan J Obstet Gynecol. 2020;59:922. 10.1016/j.tjog.2020.09.021
- Ekin M, Kaya C, Erdoğan ŞV, Bahçeci E, Baghaki S, et al. The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study. J Obstet Gynaecol. 2021;41:263. 10.1080/01443615.2020.1755628
- Scarneciu I, Bungau S, Lupu AM, Scarneciu CC, Bratu OG, et al. Efficacy of instillation treatment with hyaluronic acid in relieving symptoms in patients with BPS/IC and uncomplicated recurrent urinary tract infections - Long-term results of a multicenter study. Eur J Pharm Sci. 2019;139:105067. 10.1016/j.ejps.2019.105067
- Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. 10.5152/tud.2018.63600
- Morelli M, Mocciaro R, Venturella R, Albano A, Sacchinelli A, et al. Hyaluronic acid-chondroitin sulfate: a potential factor to select pure stress urinary incontinence in patients with interstitial cystitis⁄painful bladder syndrome and mixed incontinence symptoms. Minerva Ginecol. 2015;67:121.
- Huang W, Wang F, Wu C, Hu W. Efficacy and safety of pirarubicin combined with hyaluronic acid for non-muscle invasive bladder cancer after transurethral resection: a prospective, randomized study. Int Urol Nephrol. 2015;47:631. 10.1007/s11255-015-0940-1
- Kim A, Lim B, Song M, Choo MS. Pretreatment features to influence effectiveness of intravesical hyaluronic Acid instillation in refractory interstitial cystitis/painful bladder syndrome. Int Neurourol J. 2014;18:163. 10.5213/inj.2014.18.3.163
- Giberti C, Gallo F, Cortese P, Schenone M. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv Urol. 2013;5:175. 10.1177/1756287213490052
